Analysis in colorectal cancer with resected hepatic metastases and its relationship to metastatic characteristics and prognosis.

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We studied 35 patients who had resection of hepatic metastases from colorectal cancer.The overall three-year and five-year survival rates were 53 % and 35 %, respectively. The survival of patients with metachronous metastases (45.8 /o alive at 5 years) was slightly better than of that patients with synchronous metastases (28.3 /o alive at 5 years). No significant relationship between metastatic tumor characteristics (number of metastases, lobar distribution of metastases and size of largest lesion) and prognosis was found. Also stage of primary resected lesion and surgical methods were not related to prognosis of patients. Survival of patients with DNA diploid metastases (71 % alive at 5 years) was significantly better than that of patients with DNA aneuploid metastses (34.1 % alive at 3 years and 17.0 % alive at 5 years) (p<0.05). In a Cox multivariate regression analysis, DNA ploidy pattern was most powerful prognostic indicator in resected hepatic metastases. These results demonstrated that flow cytometric DNA ploidy measurements may have prognostic value for patients with resected hepatic metastases from colorectal cancer.
日本大腸肛門病学会の論文