Expression of Ras Oncogene p21 in colorectal cancer and adenoma.

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The expression of ras oncogene p21 was determined immunohistochemically, using an avidin-biotin peroxidase method with anti ras p21 rat monoclonal antibody (Y 13-259), in 72 carcinomas, 30 adenomas and 75 normal mucosae of the colorectum. <BR>Intense immunoreactivity for ras oncogene p21 was detected in 39 (54 %) carcinomas, in 24 (80 %) adenomas and in 7 (9 %) normal mucosae. The increased expression of ras oncogene p21 was found in the luminal surface of normal colonic mucosa. The increased expression of ras oncogene p21 was significantly higher in colorectal neoplasia than in normal mucosa and it was significantly higher in adenomas than in carcinomas. There was no correlation between the increased expression of ras oncogene p21 and the advanced stage of carcinomas. These results suggested that ras oncogene protein (p21) may play a role in the evolusion and transformation of colorectal neoplasia, as well as in the differentiation of normal colonic epithelium, but play no significant role in the progression of overt colorectal carcinomas.
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