Tissue CEA and CA19-9 staining in colorectal adenoma.

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A total of 169 colorectal polyps treated in our department during the past 5 years were surveyed. We studied the presence of CEA and CA 19-9 in 30 colonic adenomas containing focal carcinomatous glands by the PAP method and mucin alterations in all specimens using HID-AB and PAS straining. Adenomatous glands were divided into those with mild, moderate, and severe dysplasia and carcinoma. Based on the distribution patterns of CEA, localization was graded from Grade 0 to 3. Thereafter, the correlation between the histologic manifestations and the grade of CEA localization was assessed. As a result, 96 % of our cases were stained positively for CEA, whereas only 47% were positive for CA 19-9. Seventy percent had an area of more than two-thirds showing a positive CEA reaction, whereas in contrast, only 7 % showed two-thirds staining for CA 19-9. CEA showed a uniform distribution, but CA 19-9 exhibited focal or spotted staining. In general, CEA localization tended to demonstrate higher grades of reactivity with the progress of atypia. However, it was impossible to discriminate the degree of atypia, particularly between severely dysplastic glands and carcinomatous glands. It was also noted that CA 19-9 localization was not related to dysplastic changes seen in adenomas. Mucus secretion was reduced with the advance of atypia, finally resulting in almost complete depletion in carcinomatous glands. Adenomatous glands rather randomly showed sialomucin-dominant, sulfomucin-dominant or mixed patterns independent of any correlation with the degree of atypia.
日本大腸肛門病学会の論文

Tissue CEA and CA19-9 staining in colorectal adenoma.

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