Histopathological evaluation of preoperative irradiation and anti-cancer drug injection for rectal cancer.

概要

論文の詳細を見る
Thirty-four patients with rectal cancer were divided into two groups. Group R: 15 patients who received 42.6 Gy Co-irradiation for 5 weeks, prior to surgery. Group C: 19 patients to received 4 injections of peplomycin 10 mg and 5-bromodeoxyuridine (BUdR) 500 mg together with 42.6 Gy of irradiation. Histological investigation of the microscopic extension of tumor cells into the extramural tissue of the rectum was performed for these two groups using Ohoshi-Shimosato's classification. Results: Extreme effects of irradiation (over Grad IIb) were observed 4 cases (26.7 %) in Group R and 11 cases (57.9 %) in Group C. There was a significant difference (p<0.05) between the two groups. The histopathological effects of radiation were much more marked in Group C than in Group R.
日本大腸肛門病学会の論文