大腸癌に対する5種類の腫瘍マーカー (CEA, TPA, CA19-9, KMO, DUPAN-2) の診断能の検討

概要

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The clinical significances of TPA, CA 19-9, KM01 and DUPAN-2 were compared with that of CEA for diagnosis of cancer in 52 patients with colorectal cancer.<BR>Positive rates for serum concentrations of CEA, TPA, CA 19-9, KM01 and DUPAN-2 were 38.5 %, 32.7 %, 19.2 %, 11.5 % and 7.7 %, respectively. Combination assay of CEA and TPA increased the positive rate to 51.9 % because the number of patients showing a positive TPA value with a nevative CEA value was seven. On the other hand, CA 19-9 was inferior to CEA as a tumor marker for colorectal cancer because all patients positive for CA 19-9 showed a positive value for CEA. with regard to KM01 and DUPAN-2, no patient showed a positive value independently. Accordingly, no clinical usefulness of these two tumor markers was seen.<BR>These results suggested that TPA could be used as a useful tumor marker for colorectal cancer, as in the case of CEA.
日本大腸肛門病学会の論文