結腸憩室症結腸における蠕動反射とその Peptidergic Nerve 調節の変動について

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In order to evaluate the regulation of colonic peristalsis and the innervation of peptidergic nerves in diverticular disease of the colon, we studied 37 normal segments and 9 diverticular segments taken from surgical colonic material of colorectal cancer and diverticular disease of the colon, using mechanographical and electrophysiological techniques in vitro.<BR>The following results were obtained : (1) In the normal colon, the peristaltic reflex, consisting of oral contraction with a spike potential and depolarization, and anal relaxation with hyperpolarization, was regulated by non-cholinergic, non-adrenergic nerves. Substance P and neurotensin induced contraction with spike potential and depolarization, while vasoactive intestinal polypeptide induced relaxation with hyperpolarization. (2) In the colon containing diverticula, regulation of peristaltic reflex was disturbed because anal contraction instead of relaxation occurred, and this anal contractile reaction was observed even after total blocking of the nervous system with TTX. It is suggested that this anal contractile reaction in the diverticular colon is due to a myogenic factor of smooth muscle per se rather than a disturbance of non-adrenergic inhibitory nerves.
日本大腸肛門病学会の論文