On the estrogen receptor and progesterone receptor in colorectal cancer.

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概要

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• Recently, the existence of estrogen receptor (ER) in the tissue of colorectal cancer has been reported. To investigate the clinico-pathological characteristics of receptor-positive primary, colorectal cancers, biochemical assay of ER and progesterone receptor (PgR) was carried out in 38 cases, fluorescence cytochemistry in 43 cases and ER staining with monoclonal anti-ER antibody (ER-ICA) in 44 cases. Staining of endogenous estradiol (E<SUB>2</SUB>) and progesterone (PRG) in 112 primary colorectal cancers was also performed using Vectastain ABC Kit (ABC method).<BR>The positive rates were 15.8% for cytosol ER, 14.7% for nuclear ER, 15.6% for cytosol PgR and 21.4% for nuclear PgR by biochemical assay, and 16.3% for ER and 18.6% for PgR by fluorescence cytochemistry, while no positive case could be detected by ER-ICA. The positive rates by ABC method were 23.2% for E<SUB>2</SUB> and 19% for PRG.<BR>In most of the receptor-positive cases, the tumors were advanced and had infiltrated deeply into the wall of the colon and rectum. They showed a tendency to be ill-defined ulcerated cancer (Borrmann 3-like cancer), moderately differentiated adenocarcinoma, n(+), ly (+) and v (+).<BR>It seemed that fluorescence cytochemistry was better than the other methods for the detection of ER and PgR in colorectal cancers.<BR>The presence of ER and PgR in some colorectal cancers suggested the possibility that the hormones (E<SUB>2</SUB> and PRG) are concerned with colorectal cancers. Thus, endocrine therapy might contribute to the treatment of colorectal cancers.

• 日本大腸肛門病学会の論文

著者

• 高 相進

  東京医科歯科大学第1外科

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• On the estrogen receptor and progesterone receptor in colorectal cancer.

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