Clinical and histopathological evaluation of preoperative irradiation and anti-cancer drugs injection for rectal cancer.

概要

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Twenty-eight patients with rectal cancer were divided into two groups. Group I: 7 patients received 42 Gy 60Co irradiation for 5 weeks, before surgery Group II : 21 patients received 4 injections of Pepleomycin 10 mg, 5-bromodeoxyuridine (BudR) 500 mg, with 3 Gy irradiation over .10 days (12.Gy in total) after they had received 30 Gy irradiation previously.<BR>When Groups I and II were compared, tumors Group II had shrunk much more than those in Group I endoscopically, and degeneration of cancer cells was greater, histologically. In 5 cases of Group I, no cancer tissues were observed in biopsy specimens after irradiation. However in 5 cases out of 9 in Group II, a small amount of cancer tissue was observed. In histological studies of the surgical material, specimens from Group I showed much more hya-line-degenerative fibrosis than those from Group II.
日本大腸肛門病学会の論文