An ultrastructural study of colon adenomas II - Transmission electron microscopic observations of adenoma atypia.:Transmission Electron Microscopic Observations of Adenoma Atypia

概要

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Using transmission electron microscopy, we have observed the fine structures of colon adenomas which had been endoscopically or surgically removed. Several findings regarding the malignant potential of colon adenomas were obtained. 1) Even if an adenoma of the same grade shows a different histological appearance, there are no remarkable differences in its cytological appearance. 2) Serial changes in ultrastructure are recognized with increased light microscopic histological grading. 3) In particular microvillous changes show just the same changes as those observed by scanning electron microscope. 4) Cellular malignant potential can be suggested by observing the intracellular organelles and secretory granules for each grade of adenoma. In conclusion, it is considered that further investigation of cellular malignant potential must be done to facilitate earlier diagnosis and morphological pathogenesis of large bowel carcinoma.
日本大腸肛門病学会の論文