Tumor markers (CEA, X-hapaten, Y-hapten, CA 19-9 and NCC-ST-439 antigens) in the tissue of colorectal carcinoma.

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Various tumor markers of colorectal cancer have been identified, among them, carcinoembryonic antigen (CEA) has been successfully applied clinically. Using the somatic cell hybridization method, many monoclonal antibodies reactive with various cancers have been developed. Among the cancer associated antigen detected by these monoclonal antibodies, carbohydrate antigens have been shown to be important. In this paper, distribution of these tumor associated antigens including CEA, X-hapten, Y-hapten, CA 19-9 and NCC-ST-439 antigens were studied in the tissue of colorectal carcinoma and normal looking colon, using immunohistochemistry, RIA and EIA. In mucosa remote from carcinoma, CA 19-9 was not expressed, X-hapten and CEA were only faintly expressed. Y-hapten was expressed in proximal colon and not in distal colon. In mucosa adjacent to carcinoma, CA 19-9, X-hapten and CEA were faintly expressed, but NCC-ST-439 and Y-hapten were not expressed. In all cases of carcinoma, the content of NCC-ST-439 antigen and CEA was much higher than in the remote mucosa. In adenoma, the experssion of these antigens was some extent related to the degree of cellular atypia. These results show that the expression of these antigens change along with neoplastic transformation and progression in the colorectum.
日本大腸肛門病学会の論文