An ultrastructural study of colon adenomas. Scanning electron microscopic observations as to the atypia of adenomas.:Scanning Electron Microscopic Observations as to the Atypia of Adenomas

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Using SEM, we have observed fine surface structures of colon adenomas which were endoscopically or surgically removed. Several findings on the malignant potential of colon adenomas were obtained.. As the grade of atypia of the adenoma increases, the following serial changes on its surface structure are recognized: 1) disappearance of crypt, appearance of cleft and coarseness of surface, 2) decrease of goblet cells, cellular inequality in size and disruption of cellular surface, 3) shortness and gradual depletion of microvilli, And these ultrastructural findings correlate fairly well with the light microscopic histological diagnosis and grading. In conclusion, scanning electron microscopic observations can reveal cellular malignant changes of colon adenomas, and the possibility of a rather earlier diagnosis of large bowel carcinoma is implied.
日本大腸肛門病学会の論文