3. The Studies on Experimentally Induced Colonic Carcinoma in Dog by Selective Application of MNNG

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There is no report of experimentally developed colon cancer in the dog up to date. In this paper, the experimental high grade atpyical glands of colon in dog which was expected to developed into adenocarcinoma was reported. Administration procedure of MNNG was as follows;<BR>The tip of silicon tube was fixed in the ascending colon through the vermiform appendix and the other end of tube was carried out to the back of the dog through the subcutaneous tunnel. Solution of MNNG with 3 g/1 tween 60 were injected through this tube twice a week in 8 dogs.<BR>The endoscopic examination were performed regularly in each dog after the start of administration of MNNG. The administration of MNNG were varied depending on the general condition of the dogs.<BR>In one dog which was underwent of administration of 2mgMNNG/kg for weeks and 1 mg/kg for 41 weeks, the endoscopy demonstrated the lesion similar to IIc+IIa, type of early cancer. Biopsy of the lesion revealed the atypical glands in deep mucosal layer.<BR>By autopsy, this lesion was confirmed as high grade atypical glands and protrusion of its glands into submucosal layer was proved histologically.
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