T Cell Abnormalities in Mixed Connective Tissue Disease Complicated with Klinefelter's Syndrome.
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概要
- 論文の詳細を見る
We report a 28-year-old Japanese with Klinefelter's syndrome who developed mixed connective tissue disease (MCTD) and Sjögren syndrome. Previously being well, he presented with Raynaud's phenomenon, dry eye, fever and polyarthralgia. Clinical examinations revealed anti-nRNP autoantibody, leukopenia and lung fibrosis. Then he was found to have Klinefelter's syndrome. Flow cytometric analysis showed a relative increase of peripheral CD8+ T lymphocytes carrying either HLA-DR or CD57. Lymphocyte IL-2 production induced in vitro by concanavalin A was decreased. Such T cell abnormalities may be implicated in the development of autoimmune disease in Klinefelter's syndrome.(Internal Medicine 33: 714-717, 1994)
- 社団法人 日本内科学会の論文
著者
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Matsuzawa Yuji
The Second Department Of Internal Medicine Osaka University Medical School
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KANAKURA Yuzuru
The Second Department of Internal Medicine, Osaka University Medical School
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KANAYAMA Yoshio
The Second Department of Internal Medicine, Osaka University Medical School
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ISHIHARA Katsuhiko
The Second Department of Internal Medicine, Osaka University Medical School
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YOSHIMURA Masafumi
The Second Department of Internal Medicine, Osaka University Medical School
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NAKAO Hirohisa
The Second Department of Internal Medicine, Osaka University Medical School
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- T Cell Abnormalities in Mixed Connective Tissue Disease Complicated with Klinefelter's Syndrome.