Hypercalcemia Caused by PTH-rP Associated with Lung Metastasis from Urinary Bladder Carcinoma: An Autopsied Case.
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概要
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We analyzed the parathyroid-related protein (PTH-rP) content in tissue specimens obtained from a 61-year-old man with hypercalcemia associated with lung metastasis from urinary bladder carcinoma using radioimmunoassay and immunohistochemistry. Radioimmunoassay showed that the PTH-rP content was higher in metastatic lung tumor tissue than in non-tumorous lung tissue. Immunohistochemical analysis revealed the presence of PTH-rP in tumor cells. Furthermore, proliferation of osteoclasts was found in bone marrow at autopsy. The results suggest that PTH-rP induced humoral hypercalcemia of malignancy in a patient with urinary bladder cancer.(Internal Medicine 33: 673-676, 1994)
- 社団法人 日本内科学会の論文
著者
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SUZUMIYA Junji
the First Department of Internal Medicine, Fukuoka University School of Medicine
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Katakami Hideki
The Third Department Of Internal Medicine Miyazaki Medical College
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Kimura Nobuhiro
The First Department Of Internal Medicene School Of Medicine Fukuoka University
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Kikuchi Masahiro
The First Department Of Pathology Fukuoka University School Of Medicine
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Yoshida Tetsuya
The First Department Of Internal Medicine Fukuoka University School Of Medicine
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OKUMURA MAKOTO
The First Department of Internal Medicine and the Department of Anatomy, School of Medicine, Fukuoka University
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HISANO Shusuke
The First Department of Internal Medicine, School of Medicine, Fukuoka University
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YOSHIDA Tetsuya
The First Department of Internal Medicine, School of Medicine, Fukuoka University
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