Theoretical Consideration on Plasma Volume Determination

概要

論文の詳細を見る
(1) A theory has been derived from analysis of the factors shaping the dilution curve in the multiple volume compartments, assuming that injected dye moves in the plasma, according to its concentration difference between the compartments.(2) From the theoretical analysis of disappearance coefficient, it has been clarified that a) dilution process during a period of 10 minutes to 1-2 hours was governed by the mixing of dye with the plasma and removal of dye from the blood stream, b) during this period mixing was performed completely in a great number of normal individuals, whereas mixing was still in process in some patients with congestive heart failure, c) plasma volume estimated by one exponential extrapolation of dilution curve covering a period of 10 minutes to 1-2 hours was considered as the values of "space, " and d) the 10-minute method of Gregersen is useful as a simple method, but the values thus obtained do not represent the true plasma volume.(3) This theory offers an actual determination of plasma volume and the stagnant plasma volume. This appeared to be very useful clinically in case of congestive heart failure.
International Heart Journal刊行会の論文