Clinical Evaluation of KK-25-S A New Ganglionic Blocking Agent
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概要
- 論文の詳細を見る
Preliminary clinical observations are presented on the hypotensive effect of KK-25-S (N-dimethylaminopropyl-4, 7-endoethylene-4, 7, 8, 3-tetrahydro-4, 7-ethanoisoindoline), a newly synthesized ganglionic blocking agent. A significant response was obtained in 12 of 25 hypertensive cases (48%) treated with KK-25-S alone. Addition of reserpine resulted in a more favorable response, 18 of 21 cases (86%) treated with the combined therapy showing satisfactory hypotensive effect without development of significant tolerance to KK-25-S. The incidence of side effects, especially of constipation and orthostatic hypotension was less than that with other available ganglionic blocking agents. The encouraging results obtained here warrant further investigation of this drug.
- International Heart Journal刊行会の論文
著者
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SATAKE KIYOTO
Department of Internal Medicine, Nippon Medical School
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Satake Kiyoto
Department Of Internal Medicine Nippon Medical School
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HANNYA Hiroshi
Department of Internal Medicine, Nippon Medical School
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Kimura Eiichi
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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YAHATA Koji
Department of Internal Medicine, Nippon Medical School
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