Fatal Encephalitis in a Case of Hypereosinophilic Syndrome: MRI and Autopsy Findings
スポンサーリンク
概要
- 論文の詳細を見る
A 34-year-old man developed fever and headache, followed by finger tremor and gait disturbance, and was admitted to our hospital about two months after onset. Blood tests showed a white blood cell count of 32,600 /μL with an eosinophil count of 22,300 /μL. There was no evidence of allergic drug reaction or parasitic infection. Cerebrospinal fluid examination demonstrated mononuclear pleocytosis without eosinophils or atypical cells. Brain MRI showed symmetric lesions bilaterally in the medial temporal lobe, frontobasal and insular regions and medulla oblongata. Herpes simplex virus-DNA was negative in the cerebrospinal fluid. The patient died about four months after onset. Histopathologically, there was infiltration of T cells, B cells and macrophages throughout the whole brain, but eosinophils or atypical cells were absent. Immunohistochemistry for herpes simplex virus type 1 and human herpesvirus 6 was negative. This case suggests that fatal encephalitis may develop in association with hypereosinophilic syndrome.
著者
-
Tsuchiya Kuniaki
Department Of Laboratory Medicine And Pathology Metropolitan Matsuzawa Hospital
-
Arai Tetsuaki
Department Of Neuropathology Tokyo Institute Of Psychiatry
-
Yokota Osamu
Department Of Neuropathology Tokyo Institute Of Psychiatry
-
Miki Kazunori
Department Of Neurology And Neurological Science Graduate School Of Medicine Tokyo Medical And Denta
-
Mizusawa Hidehiro
Department Of Neurology And Neurological Science (chairman: Prof. Hidehiro Mizusawa) Graduate School
-
Ishizu Hideki
Department Of Laboratory And Medicine Zikei Institute
-
Miake Hirotomo
Department Of Neurology Musashino Redcross Hospital
-
Akiyama Haruhiko
Department Of Neuropathology Psychiatric Research Institute Of Tokyo
-
Kobayashi Zen
Department Of Neurology And Neurological Science Graduate School Tokyo Medical And Dental University
-
Tsuchiya Kuniaki
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Japan
-
Arai Tetsuaki
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Japan
-
Komachi Hiroshi
University Health Center, Chuo University, Japan
-
Akiyama Haruhiko
Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Japan
-
Yokota Osamu
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
関連論文
- Control of chondrogenesis by the transcription factor Sox9
- Long-term survivorship analysis of hip arthroplasty with vitallium mold cup
- Progressive supranuclear palsy combined with Alzheimer's disease : A clinicopathological study of two autopsy cases
- Corticobasal degeneration as cause of progressive non-fluent aphasia : Clinical, radiological and pathological study of an autopsy case
- Longitudinal Observation of a Patient with Leri-Weill Dyschondrosteosis and SHOX Haploinsufficiency
- Identification of Septins in the Neurofibrillary Tangles in Alzheimer's Disease
- Basal ganglia lesions in 'Pick complex' : A topographic neuropathological study of 19 autopsy cases
- Distribution of basal ganglia lesions in Pick's disease with Pick bodies : A topographic neuropathological study of eight autopsy cases
- Geographic Difference of Mortality of Creutzfeldt-Jakob Disease in Japan
- Pick's disease with Pick bodies : An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron
- Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease : A non-demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala
- Aging of the human limbic system: Observations of centenarian brains and analyses of genetic risk factors for senile changes
- A clinical and genetic study in a large cohort of patients with spinocerebellar ataxia type 6
- Basal ganglia lesions in corticobasal degeneration differ from those in Pick's disease and progressive supranuclear palsy: A topographic neuropathological study of six autopsy cases
- Selective enlargement of the fourth ventricle in Machado-Joseph disase: With special reference to the neuroradiological and neuropathological correlation
- Dentatorubropallidoluysian atrophy : Clinicopathological study of eight autopsy cases with special reference to the clinicopathological correlation between pyramidal sign and involvement of the pyramidal tract
- QUANTITATION OF THE MYOCARDIAL INFARCT SIZE BY COMPUTER-ASSISTED ANALYSIS OF THE Gd-DTPA ENHANCED MAGNETIC RESONANCE IMAGING ( MRI )
- Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan
- Immunohistochemical Diagnosis of Cryptococcus neoformans var. gattii Infection in Chronic Meningoencephalitis : the First Case in Japan
- Guidelines for the treatment of Crohn's disease in children
- A unique type of multiple system degeneration involving the subthalamic nucleus, substantia nigra, dentate nucleus, superior olivary nucleus, and posterior column: A clinicopathological study
- A -16C>T substitution in the 5' UTR of the puratrophin-1 gene is prevalent in autosomal dominant cerebellar ataxia in Nagano
- Ultrastructural and MRI study of the substantia nigra evolving exofocal post-ischemic neuronal death in the rat
- Distribution of cerebello-olivary degeneration in idiopathic late cortical cerebellar atrophy : Clinicopathological study of four autopsy cases
- Sporadic amyotrophic lateral sclerosis of long duration mimicking spinal progressive muscular atrophy exists : Additional autopsy case with a clinical course of 19 years
- Presenile dementia mimicking Pick's disease : An autopsy case of localized amygdala degeneration with character change and emotional disorder
- Rapidly Progressed Acquired Immunodeficiency Syndrome Dementia Complex as an Initial Manifestation
- Skeletal Muscle MRI in Complex Regional Pain Syndrome
- Classification of Cerebellar Atrophy Using Voxel-based Morphometry and SPECT with an Easy Z-score Imaging System
- Alcoholic cerebellar degeneration : A clinicopathological study of six Japanese autopsy cases and proposed potential progression pattern in the cerebellar lesion
- Lewy body variant of Alzheimer's disease or cerebral type Lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem
- TNF-related apoptosis-inducing ligand (TRAIL) induces neuronal apoptosis in HIV-encephalopathy
- Neurofibrillary tangles and deposition of oxidative products in the brain in cases of myotonic dystrophy
- Degeneration of the inferior olive in spinocerebellar ataxia 6 may depend on disease duration : Report of two autopsy cases and statistical analysis of autopsy cases reported to date
- Coexistence of CJD and Alzheimer's disease : An autopsy case showing typical clinical features of CJD
- Sporadic amyotrophic lateral sclerosis with circumscribed temporal atrophy : A report of an autopsy case without dementia and with ubiquitinated intraneuronal inclusions
- Parkinson's disease mimicking senile dementia of the Alzheimer type : a clinicopathological study of four autopsy cases
- Sporadic amyotrophic lateral sclerosis resembling primary lateral sclerosis : Report of an autopsy case and a review of the literature
- "Forme fruste" of amyotrophic lateral sclerosis with dementia : A report of five autopsy cases without dementia and with ubiquitinated intraneuronal inclusions
- Methotrexate-related leukoencephalopathy without radiation therapy : Distribution of brain lesions and pathological heterogeneity on two autopsy cases
- White matter changes in early-onset Alzheimer's disease brains
- Demonstration and distribution of tau-positive glial coiled body-like structures in white matter and white matter threads in early onset Alzheimer's disease
- UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase in nuclei and rimmed vacuoles of muscle fibers in DMRV (distal myopathy with rimmed vacuoles)
- Pick body disease : A proposal
- A linkage disequilibrium at the candidate gene locus for 16q-linked autosomal dominant cerebellar ataxia type III in Japan
- Subacute speech apraxia and consciousness disturbance in a 57-year-old non-alcoholic man
- An autopsy case of postencephalitic parkinsonism of von Economo type : Some new observations concerning neurofibrillary tangles and astrocytic tangles
- Frontotemporal dementia : Pick type
- Demonstration of ganglioside GD3 in human reactive astrocytes
- Introduction of Short Interfering RNA to Silence Endogenous E-Selectin in Vascular Endothelium Leads to Successful Inhibition of Leukocyte Adhesion
- Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia
- アルツハイマー型認知症の海馬におけるネプリライシン、ソマトスタチンおよびソマトスタチン受容体 type5 の発現
- Fatal Encephalitis in a Case of Hypereosinophilic Syndrome: MRI and Autopsy Findings
- Two region-dependent pathways of eosinophilic neuronal death after transient cerebral ischemia
- Direct and accurate measurement of CAG repeat configuration in the ataxin-1 (ATXN-1) gene by "dual-fluorescence labeled PCR-restriction fragment length analysis"
- A pathological study of Lewy bodies and senile changes in the amygdala in diffuse Lewy body disease
- Analyses of copy number and mRNA expression level of the α-synuclein gene in multiple system atrophy
- Lectin cytochemistry of rat cerebral and cerebellar neuronal cells
- Uitracytochemical demonstration of the polarity of Ca^2+-ATPase activity in microglia
- Ganglioside GD3 of cerebral neurons and Purkinje cells in aged human brains
- Ultracytochemical localization of Ca^-ATPase activity in microglia
- On autosomal dominant cerebellar ataxia (ADCA) other than polyglutamine diseases, with special reference to chromosome 16q22.1-linked ADCA
- Differential Expressions of BMP Family Genes during Chondrogenic Differentiation of Mouse ATDC5 Cells
- Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease
- Pick body disease and Pick syndrome
- Increase of cytochrome c oxidase negative fibers in rimmed vacuole myopathy with inflammatory changes
- Computed tomography-based navigation for curved periacetabular osteotomy
- Glial tangles in Pick's disease
- [^I]Meta-iodobenzylguanidine Myocardial Scintigraphy Differentiates Corticobasal Degeneration from Parkinson's Disease
- Urinary sulfated bile acid concentrations in infants with biliary atresia and breast-feeding jaundice
- Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres
- A Mother and a Child with Maternally Inherited Diabetes and Deafness (MIDD) Showing Atrophy of the Cerebrum, Cerebellum and Brainstem on Magnetic Resonance Imaging (MRI)
- Home Health Care in Patients with Neurologic Impairments in Rural Area in Japan : What is the Long-term Survival-determining Factor?
- The risk of iatrogenic Creutzfeldt-Jakob disease through medical and surgical procedures
- Dura mater graft-associated Creutzfeldt-Jakob disease in Japan : Clinicopathological and molecular characterization of the two distinct subtypes
- Predominant motor symptoms in a 74-year-old man with a small elongation in the spinocerebellar atrophy type 1 gene
- Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease
- Motor neuron disease group accompanied by inclusions of unidentified protein signaled by ubiquitin
- Generation of transgenic mice for conditional overexpression of Sox9
- Effects of pericyte and various cytokines on integrity of endothelial monolayer originated from blood-nerve barrier : An in vitro study
- An autopsy case of Creutzfeldt-Jakob disease with a V180I mutation of the PrP gene and Alzheimer-type pathology
- Morel's laminar sclerosis showing apraxia of speech : Distribution of cortical lesions in an autopsy case
- Differential diagnosis of CNS lymphomatoid granulomatosis
- Anticholinergic Drugs and Cognitive Functions
- Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy
- Alternative BSE Risk Assessment Methodology of Imported Beef and Beef Offal to Japan
- Significant increase in the expression of matrix metalloproteinase 7 in primary CNS lymphoma
- Clinical heterogeneity in progressive supranuclear palsy : Problems of clinical diagnostic criteria of NINDS-SPSP in a retrospective study of seven Japanese autopsy cases
- 5-FU-induced Acute Leukoencephalopathy
- Argyrophilic grain disease with delusions and hallucinations : a pathological study
- Duration of Prion Disease is Longer in Japan Than in Other Countries
- Mucin core protein expression by colorectal mucinous carcinomas with or without mucus hyperplasia
- Prevalence of inositol 1, 4, 5-triphosphate receptor type 1 gene deletion, the mutation for spinocerebellar ataxia type 15, in Japan screened by gene dosage
- Efficient in vivo delivery of antisense oligonucleotide to choroid plexus
- Chronic Inflammatory Demyelinating Polyradiculoneuropathy in a Patient with Crohn's Disease
- Metronidazole-induced Encephalopathy
- Bilateral Facial Nerve Palsy Caused by a Metastatic Malignant Lymphoma
- Progression of Bilateral Internal Carotid Artery Dissection during Antiplatelet Therapy
- Intramedullary Spinal Cord Metastasis with a Longitudinally Extensive Spinal Cord Lesion
- Pseudoradicular Sensory Loss Caused by a Cerebral Demyelinative Lesion