The Role of Free Radicals and Neutrophil Elastase in Development of Pulmonary Emphysema.
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概要
- 論文の詳細を見る
Extracellular proteolysis is hypothesized to be the major cause of pulmonary emphysema and oxygen-derived free radicals and neutrophil elastase are thought to play an important role in its pathogenesis. In this study, peripheral polymorphonuclear leukocytes (PMNs) obtained from 16 patients with emphysema generated a significantly larger amount of superoxide and elastase activity than those obtained from normal controls. A significant correlation was observed between elastase activity and superoxide release. In addition, the superoxide releaseshowed a negative correlation with the disease duration. The superoxide release appeared to correlated with a decline of FEV1.0 over the course of several years in 8 patients. It seems likely that activated PMN splay an important role in the development of pulmonary emphysema.(Internal Medicine 31 : 857-860, 1992)
- 社団法人 日本内科学会の論文
著者
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Takeda Tadanao
The First Department Of Internal Medicine Osaka City University Medical School
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FUJIMOTO Shigeo
the First Department of Internal Medicine, Osaka City University Medical school
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KURIHARA Naotsugu
the First Department of Internal Medicine, Osaka City University Medical school
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HIRATA Kazuto
the First Department of Internal Medicine, Osaka City University Medical school
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KANAZAWA Hiroshi
The First Department of Internal Medicine, Osaka City University Medical School
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TAKEDA Tadanao
the First Department of Internal Medicine, Osaka City University Medical school
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