Leukoencephalopathy Induced by Tegafur: Serial Studies of Somatosensory Evoked Potentials and Cerebrospinal Fluid.

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概要

• 論文の詳細を見る

• A case of leukoencephalopathy induced by tegafur, an antineoplastic derivative of 5-FU, is reported. The patient received 600mg of tegafur p. o. for 16 days before excision of rectal cancer. After the operation, gait disturbance and mental abnormalities appeared. He became akinetic and mute within a few days following readministration of tegafur. Serial studies of brain CT, somatosensory evoked potentials (SEP) were made, and myelin basic proteins (MBP) in the cerebrospinal fluid were measured. The level of MBP was about twice the normal value and the central conduction time (CCT) of SEP was prolonged at admission. The value of MBP and CCT improved with recovery from akinetic mutism.(Internal Medicine 31 : 828-831, 1992)

• 社団法人　日本内科学会の論文

著者

• Hanyu Norinao

  The Department Of Neurology Nagano Red-cross Hospital

• HAYASHI Ryoichi

  The Department of Neurology, Nagano Red Cross Hospital

• KITAHARA Akihiko

  the Department of Psychiatry, Nagano Red Cross Hospital

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• Leukoencephalopathy Induced by Tegafur: Serial Studies of Somatosensory Evoked Potentials and Cerebrospinal Fluid.

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