Eosinophil Viability-Enhancing Activity in Mite-Sensitive Bronchial Asthma.
スポンサーリンク
概要
- 論文の詳細を見る
We examined the eosinophil viability-enhancing activity (EVEA) of peripheral blood mononuclear cells (PBMNCs) obtained from 6 patients with mite-sensitive bronchial asthma (BA) and 9 normal control subjects. Mite concentrations of 1μg/ml and 10 μg/ml significantly increased EVEA in PBMNC culture supernatants from BA patients compared with PBMNCs from normal control subjects (76.1±11.0% at 10 μg/ml and 56.3±16.0% at 1 μg/ml vs 20.6±012.6% at 10 μg/ml and 7.4±2.3% at 1 μg/ml; p<0.05). The level of IFN-γ in PBMNC culture supernatants in BA patients was 2.3±0.9 IU/ml and in normal control subjects 0.7±0.3 lU/ml. A combination of mAbs (anti-IL3, anti-IL-5 and anti-GM-CSF, with or without anti-IFN-γ) neutralized the EVEA (p<0.001, p<0.001, respectively). Dexamethasone (10-8 M to 10-5 M), cyclosporin A (10-7 M to 10-5 M) and FK506 (10-8 M to 10-6 M) significantly inhibited EVEA in BA patients (p<0.05 to p<0.001). The release of eosinophil cationic protein (ECP) from eosinophils in the presence of mite-stimulated PBMNC culture supernatants was higher in patients with bronchial asthma (569±147 μg/l) than in normal control subjects (203±99 μg/1; p<0.05).(Internal Medicine 33: 529-535, 1994)
著者
-
Hossain Mahboob
The First Department Of Internal Medicine Shinshu University School Of Medicine
-
Sekiguchi Morie
The First Department Of Internal Medicine Shinshu University School Of Medicine
-
Okubo Yoshio
The First Department Of Internal Medicine Shinshu University School Of Medicine
-
Hossain Mahboob
the First Department of Internal Medicine, Shinshu University School of Medicine
関連論文
- 7) LONG-TERM PROGNOSIS OF PRIMARY ENDOCARDIAL FIBROELASTOSIS: CLINICAL AND HISTOPATHOLOGICAL ANALYSIS BY ENDOMYOCARDIAL BIOPSY
- Acute Hypoxic Pulmonary Vascular Response Does Not Accompany Plasma Endothelin-1 Elevation in Subjects Susceptible to High Altitude Pulmonary Edema
- Effect of Prone Position on Apnea Severity in Obstructive Sleep Apnea
- IS030 Antisense bcl-x Oligonucleotide Induces Apoptosis and Prevents Arterial Neointimal Formation in Murine Cardiac Allografts
- IS030 Prevention of Cardiac Allograft Arteriosclerosis with Single Intraluminal Delivery of Decoy to Transcription Factor E2F
- Pulmonary Hypertension as a Result of Asymptomatic Portosystemic Shunt
- IS108 Clinical and prognostic significance of myocardial fatty acid metabolic changes before and during beta-blocker therapy in patients with dilated cardiomyopathy
- Familial Sick Sinus Syndrome With Atrioventricular Conduction Disturbance
- Diffuse Pulmonary Amyloidosis with Monoclonal IgG-kappa Gammopathy
- INSULIN-LIKE GROWTH FACTOR I RECEPTORS IN HUMAN CARDIAC MYOCYTES AND THEIR RELATION TO MYOCARDIAL HYPERTROPHY
- 18) HOLTER MONITOR ANALYSIS IN CASES WITH HYPERTROPHIC AND DILATED CARDIOMYOPATHY
- Inhibitory Effects of Theophylline and Procaterol on Eosinophil Function
- Interleukin-13 but Not Interleukin-4 Prolongs Eosinophil Survival and Induces Eosinophil Chemotaxis
- Successful Treatment of Fungus Ball in a Patient with Allergic Bronchopulmonary Aspergillosis: Continuous Percutaneous Instillation of Antifungal Agents into the Cavity
- Periodic Angioedema with Eosinophilia: Increased Serum Level of Interleukin 5
- IL-5 Predominant in Bronchoalveolar Lavage Fluid and Peripheral Blood in a Patient with Acute Eosinophilic Pneumonia
- COMPUTERIZED M-MODE ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT VENTRICULAR DIASTOLIC FUNCTION IN PATIENTS WITH FAMILIAL AMYLOID POLYNEUROPATHY : 51st Annual Meeting of the Japanese Circulation Society
- Eosinophil Viability-Enhancing Activity in Mite-Sensitive Bronchial Asthma.
- Radiographic and Hemodynamic Changes during Recovery from High-Altitude Pulmonary Edema.