A Patient with Chronic Hepatitis C Who Simultaneously Developed Interstitial Pneumonia, Hemolytic Anemia and Cholestatic Liver Dysfunction after Alpha-Interferon Administration
スポンサーリンク
概要
- 論文の詳細を見る
Following a three-week administration of alpha-interferon (IFN-α), a 62-year-old woman with chronic hepatitis C manifested fever and dyspnea and showed diffuse infiltrative opacities on chest roentgenograms. Her laboratory data included results of anemia with reticulocytosis, a decreased complement level and hepatitis with elevated ALP, LDH and γ-GTP, Because laboratory data also revealed a positive lymphocyte stimulation test for IFN-α, this cytokine was considered to be responsible for the development of interstitial pneumonia, hemolytic anemia and cholestatic liver dysfunction due to its immunomodulatory effects. Although these three disorders have been reported to develop singly after IFN-α therapy, this is the first report of a patient in whom these disorders occurred simultaneously.(Internal Medicine 33: 337-341, 1994)
著者
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Yamaguchi Etsuro
The First Department Of Medicine Hokkaido University School Of Medicine
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Kawakami Yoshikazu
The First Department Of Internal Medicine School Of Medicine Hokkaido University
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MATSUSHIMA Takashi
The First and the Third Department of Medicine, Hokkaido University
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HIZAWA Nobuyuki
The First and the Third Department of Medicine, Hokkaido University
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KOJIMA Junichiro
The First and the Third Department of Medicine, Hokkaido University
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KOJIMA Tetsuya
The First and the Third Department of Medicine, Hokkaido University
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SUKOH Noriaki
The First and the Third Department of Medicine, Hokkaido University
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KAWAKAMI Yoshikazu
The First and the Third Department of Medicine, Hokkaido University
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