Mode of Action of New Anti-Arrhythmic Agents
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概要
- 論文の詳細を見る
Propranolol, diphenylhydantoin and tetrodotoxin showed inhibitory or removal effects on fibrillation induced in isolated rabbit atrial muscle strip. Depending upon methods of induction of fibrillation, effects of these drugs were different. The mode of their action seemed to be due to following electrical natures of each drug in its effective dose.Diphenylhydantoin decreased rate of rise and amplitude of the action potential of dog ventricular fibers and rabbit atrial fibers, which was also a cause of prolongation of conduction time. Duration of action potential was slightly prolonged in an effective low concentration. In contrast propranolol showed a relatively little effect on these items, but depressed ectopic spontaneous activity. Tetrodotoxin had both effects more markedly.
- International Heart Journal刊行会の論文
著者
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Sano Toyomi
Instilute For Cardiovascular Diseases Tokyo Medical And Dental Univ
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Sano Toyomi
1 st Department of Internal Medicine Tokyo Medical and Dental University
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Sano Toyomi
Inst. For Cardiovasc. Dis. Tokyo Med. & Dental Univ.
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IIDA Yutaka
Institute for Cardiovascular Diseases, Tokyo Medical and Dental University
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SATO Sadayuki
Institute for Cardiovascular Diseases, Tokyo Medical and Dental University
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Sano Toyomi
Professor Of Institute For Cardiovascular Diseases School Of Medicine Tokyo Medical And Dental Unive
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Suzuki Fumio
Institute For Cardiovascular Diseases Tokyo Medica And Dental Univ. School Of Med.
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