Nucleic Acid Metabolism in Experimentally Hypertrophied Myocardium
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概要
- 論文の詳細を見る
From the experiment on the rat heart slices the following results were obtained.(1) About 25 per cent of RNA ribose were synthesized via the oxidative pentose pathway and approximately 75 per cent via the non-oxidative one in normal ventricular myocardium. This ratio is same as that of liver.(2) The synthesis of RNA ribose via the oxidative pentose pathway appeared suppressed in hypertrophied myocardial slices.(3) Despite an increase in RNA content of hypertrophied myocardium, the function i.e. the incorporation rate (C14-RNA/RNA content) were apparently decreased.(4) As for the relationship between DNA and the oxidative pentose pathway, no relation could be found. Moreover, there was no change in the incorporation rate of DNA in hypertrophied myocardium employed in this study.
- International Heart Journal刊行会の論文
著者
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KISHII Toshiaki
Department of Internal Medicine , Branch Hospital, Tokyo University
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MATSUMOTO Shinsaku
Department of Internal Medicine , Branch Hospital, Tokyo University
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Kobayashi Tachio
Department Of Gynecology And Obstetrics The Tokyo University Branch Hospital
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Ito Yoshio
Department of Appleed Chemiaity and Bialownology,Facutory of Enginiaring,niigata Institute of Technology
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KOBAYASHI Tachio
Department of Internal Medicine, Branch Hopital, University of Tokyo
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KISHII Toshiaki
Department of Internal Medicine, Branch Hopital, University of Tokyo
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MATSUMOTO Shinsaku
Department of Internal Medicine, Branch Hopital, University of Tokyo
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ITO Yoshio
Department of Internal Medicine, Branch Hopital, University of Tokyo
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- Nucleic Acid Metabolism in Experimentally Hypertrophied Myocardium