A Unique Case of Sporadic Creutzfeldt-Jacob Disease Presenting as Progressive Supranuclear Palsy.
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概要
- 論文の詳細を見る
We report a Japanese case of sporadic Creutzfeldt-Jakob disease (CJD) presenting as progressive supranuclear palsy. For 2 years after onset, neurological deficits had slowly progressed but neither myoclonusnor periodic synchronous discharge was observed. Diffusion-weighted image (DWI) showed unique high signal lesions in the bilateral frontal cortex, left parietooccipital and occipital cortices, but there was nearly no change eight months later. Needle biopsy revealed deposition of prion protein of a patchy/perivacuolar type with spongiform degeneration. Thus, the phenotype of sporadic CJD seems variable and DWI should be performed, even in atypical cases lacking the characteristics of CJD.(Internal Medicine 42: 195-198, 2003)
- 社団法人 日本内科学会の論文
著者
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HIRANO Teruyuki
the Department of Neurology, Kumamoto University School of Medicine
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Shimamura Munehisa
The Department Of Neurology And Strokology Kumamoto City Hospital
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Uchino Makoto
The Department Of Neurology Kumamoto University School Of Medicine
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Uyama Eiichiro
The Department Of Neurology Kumamoto University School Of Medicine
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Hirano Teruyuki
The Department Of Neurology Austin And Repatriation Medical Centre
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SHIMAMURA Munehisa
The Department of Neurology, Kumamoto University School of Medicine
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MURAKAMI Tatsuhumi
The Department of Neurology, Kumamoto University School of Medicine
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MlTA Shuji
The Department of Neurology, Kumamoto University School of Medicine
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KlTAMOTO Tetsuyuki
The Department of Neurological Science, Tohoku University School of Medicine
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