Effects of Antiarrhythmic Agents and Mg2+ on Aconitine-induced Arrhythmias

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概要

• 論文の詳細を見る

• The effects of antiarrhythmic agents, including Classes I and IV and 3-10mM Mg2+ on aconitine-induced arrhythmias were examined using a conventional microelectrode and patch clamp method in Langendorff-perfused rabbit hearts and isolated guinea-pig ventricular myocytes. Intracoronary application of 0.1μM aconitine induced polymorphic ventricular tachycardia (PVT) which continued for more than 60 minutes. Application of aconitine to ventricular myocytes caused a prolonged action potential duration (APD) and the appearance of early afterdepolarization (EAD) together with the occurrence of an inward hump of the I-V curve around -60 to -40mV and increased outward current at positive voltages. Application of 10μM TTX and 5mM or higher Mg2+ restored aconitine-induced PVT to sinus rhythm in Langendorffperfused preparations and also shortened the prolonged APD, demonstrating the abolishment of EAD by aconitine in ventricular myocytes. However, antiarrhythmic agents did not exert such effects. In conclusion, the antiarrhythmic actions of Mg2+ and TTX in aconitine-induced arrhythmia are to abolish EAD and shorten the prolonged APD by suppression of the inward Na+ current around -60 to -40mV.

• International Heart Journal刊行会の論文

著者

• SAWANOBORI TOHRU

  Department of Cardiovascular Disease, Medical Research Institute Tokyo Medical and Dental University

• Adaniya Hitoshi

  Department of Cardiovascular Disease, MRl, Tokyo Medical and Dental University

• Adaniya Hitoshi

  Department Of Cardiovascular Diseases Medical Research Institute Tokyo Medical And Dental University

• Sawanobori Tohru

  Department Of Cardiovascular Diseases Medical Research Institute Tokyo Medical And Dental University

• Sawanobori Tohru

  Department Of Cardiovascular Diseases Mri Tokyo Medical And Dental University

• Hiraoka Masayasu

  Department Of Cardilvascular Disease Medical Research Institute Tokyo Medical And Dental University

• Hirano Yuji

  Department Of Cardiovascular Disease Medical Research Institute Tokyo Medical And Dental University

• Hirano Yuji

  Department Of Cardiovascular Diseases Division Of Medical Science Medical Research Institute Tokyo M

• Hirano Yuuzi

  Department Of Cardiovascular Diseases Division Of Medical Science Medical Research Institute Tokyo M

• Hirano Yuuzi

  Department Of Cardiovascular Diseases Medical Research Institute Tokyo Medical And Dental University

• Sawanobori Tohru

  Dept. Cardiovasc. Dis. Mri Tokyo Med. And Dent. Univ.

• Hiraoka Masayasu

  Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University

• Hirano Yuji

  Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University

• Adaniya Hitosi

  Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University

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