Regulation and Failure of Coronary Circulation
スポンサーリンク
概要
- 論文の詳細を見る
Endothelial driving factors pathophysiologically affect the regulation of coronary circulation.To investigate the regulation of vascular function by endothelium-derived relaxing factor (EDRF) and endothelial cells, endothelium-dependent relaxation impairment was studied in acute ischemia-reperfusion injury in large coronary artery and coronary microvasculature. EDRF (NO) production and release were inhibited due to ischemia-reperfusion injury to the endothelium of large coronary arteries. There was an increased sensitivity selective to ET-1 in large coronary arteries exposed to ischemia and reperfusion. Reduced endothelium-dependent relaxation and augmented ET-1 sensitivity in large coronary arteries suggest the existence of spasmogeneity in reperfused blood vessels.Ischemia and reperfusion also brought about various morphological and functional changes in the reperfused coronary microvasculature. Edema of perivascular interstitium and endothelial cells was the main observation and caused a decrease in the ability of the microvascular bed to dilate because of extravascular compression.To examine the long-term suppression of NO synthesis accompanying endothelial dysfunction, the long-term reactions of coronary arteries and myocardium due to chronic inhibition of NO synthesis by continuously infused L-NAME was investigated. Endothelial cell impairment, proliferation and disarrangement of medial smooth muscle cells, microvascular injury due to platelet thrombi and increased perivascular fibrous tissue were found in rat coronary arteries. Myocardial fibrosis due to coronary microvascular injury was observed. These changes in coronary arterial and myocardial structure were suppressed by ACE inhibitors. Therefore, ACE inhibitors are useful in the treatment of coronary microvascular impairments.
- International Heart Journal刊行会の論文
著者
-
Miura Mamoru
Second Department of Internal Medicine, Akita University School of Medicine
-
Miura Mamoru
Second Department Of Internal Medicine Akita University School Of Medicine
関連論文
- Ca^ Overload Evokes a Transient Outward Current in Guinea-Pig Ventricular Myocytes
- Long-Term Prognosis in Patients with Silent Myocardial Ischemia (SMI)
- 0952 MECHANISM FOR BEAT-TO-BEAT VARIATION OF ECG IN ARRHYTHMIC HEART : ROLE OF MECHANO-SENSITIVE CHANNELS
- The Experimental Study of the Coronary Reperfusion in the Acute Myocardial Ischemia : The Feasibility of the Myocardial Salvage : 50th Annual Scientific Session of the Japanese Circulation Society
- Does Central Venous Pressure Reflect the Circulating Blood Volume for the Decrement of Compliance Just After Esophagectomy?
- CARDIAC AUTONOMIC NERVOUS ACTIVITY DURING EXERCISE-INDUCED MYOCARDIAL ISCHEMIA:THE DIFFERENCE BETWEEN SYMPTOMATIC AND ASYMPTOMATIC MYOCARDIAL ISCHEMIA
- Low molecular weight heparin prevents coronary and renal microvesseldisease induced by chronic NO synthase inhibition in rat
- 0429 Effects of Calcium Antagonism and Beta-Blockade on the Heart Under Chronic Nitric Oxide Synthase Inhibition in Rat
- -P096- Effects of Diltiazem on the Myocardial Structure and Coronary Vasculature Under Chronic Nitric Oxide Synthase Inhibition in in vivo Rat Model(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Down-regulation of Large Conductance Calcium-activated Potassium Channel Expression in Atherosclerotic Arteries
- Analysis of the gap of opening timing between tricuspid and mitral valve in dilated cardiomyopathy
- Altered Expression of Intermediate Conductance Calcium-Activated Potassium Channels Induced by Long-Term Blockade of Nitric Oxide Synthesis
- -0936- SUBLETHAL ISCHEMIA DELAYS THE ONSET OF CO2 LATE FALL IN THE SUBSEQUENT SUSTAINED ISCHEMIA(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- EFFECTS OF POTASSIUM CHANNEL OPENERS ON ALTERED MYOCARDIAL RESPONSE TO ISCHEMIA IN ISCHEMIA-SENSITIZED MYOCARDIUM
- Ventricular Septal Defect Secondary to Non-Penetrating Chest Trauma
- The Protection of the Acute Ischemic Myocardium: Merits and Demerits of the Coronary Reperfusion : SYMPOSIUM ON PROTECTION OF ISCHEMIC MYOCARDIUM : Basic and Clinical Research
- Effect of suplatast tosilate on cough variant asthma
- Regulation and Failure of Coronary Circulation