Cross-bridge-dependent Changes in the Intracellular Ca2+ Concentration in Mammalian Cardiac Muscles.
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概要
- 論文の詳細を見る
A change in muscle length significantly alters the developed tension in mammalian cardiac muscle compared to that in skeletal muscle fibers. The intracellular mechanisms related to the length-dependent change in developed tension have been studied using Ca2+ indicators in intact preparations; a crossbridge-dependent change in the affinity of troponin-C for Ca2+ is a possible mechanism. This hypothesis is further supported by the measurement of Ca2+ bound to troponin-C in skinned preparations. The molecular mechanism of the cross-bridge-dependent change in the affinity of troponin-C for Ca2+ is not fully understood although the studies which employ the substitution of troponin-C in skinned preparations, transgenic animals and in an animal model with heart disease have been performed. We reviewed the current studies by analyzing the intracellular mechanism responsible for the length-dependent change in tension development in mammalian cardiac muscle.
- International Heart Journal刊行会の論文
著者
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Komukai Kimiaki
Department of Cardiology, Jikei University
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Kurihara Satoshi
Department Of Cell Physiology The Jikei University School Of Medicine
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