Half-Logistic Time Constants as Inotropic and Lusitropic Indices for Four Sequential Phases of Isometric Tension Curves in Isolated Rabbit and Mouse Papillary Muscles
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概要
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The waveforms of myocardial tension and left ventricular (LV) pressure curves are useful for evaluating myocardial and LV performance, and especially for inotropism and lusitropism. Recently, we found that half-logistic (h-L) functions provide better fits for the two partial rising and two partial falling phases of the isovolumic LV pressure curve compared to mono-exponential (m-E) functions, and that the h-L time constants for the four sequential phases are superior inotropic and lusitropic indices compared to the m-E time constants. In the present study, we tested the hypothesis that the four sequential phases of the isometric tension curves in mammalian cardiac muscles could be curve-fitted accurately using h-L functions. The h-L and m-E curve-fits were compared for the four phases of the isometric twitch tension curves in 7 isolated rabbit right ventricular and 15 isolated mouse LV papillary muscles. The isometric tension curves were evaluated in the four temporal phases: from the beginning of twitch stimulation to the maximum of the first order time derivative of tension (dF/dtmax) (Phase I), from dF/dtmax to the peak tension (Phase II), from the peak tension to the minimum of the first order time derivative of tension (dF/dtmin) (Phase III), and from dF/dtmin to the resting tension (Phase IV). The mean h-L correlation coefficients (r) of 0.9958, 0.9996, 0.9995, and 0.9999 in rabbit and 0.9950, 0.9996, 0.9994, and 0.9997 in mouse for Phases I, II, III, and IV, respectively, were higher than the respective m-E r-values (P < 0.001). The h-L function quantifies the amplitudes and time courses of the two partial rising and two partial falling phases of the isometric tension curve, and the h-L time constants for the four partial phases serve as accurate and useful indices for estimation of inotropic and lusitropic effects.
著者
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Arita Hideko
Department Of Anesthesiology And Pain Relief Center The University Of Tokyo Hospital
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Hanaoka Kazuo
Department Of Anesthesia University Of Tokyo Hospital
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Otsuji Mikiya
Department Of Anesthesiology Faculty Of Medicine The University Of Tokyo
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Morita Shigeho
Department Of Anesthesia And Critical Care Teikyo University School Of Medicine
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Hirano Shuta
Department Of Cardiovascular Center Shin-katsushika Hospital
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Kurihara Satoshi
Department Of Cell Physiology The Jikei University School Of Medicine
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Kurihara Satoshi
Department of Cell Physiology, The Jikei University School of Medicine
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MIZUNO Ju
Department of Anesthesiology and the Intensive Care Unit, Teikyo University School of Medicine
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Hirano Shuta
Department of Cell Physiology, The Jikei University School of Medicine
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Kusakari Yoichiro
Department of Cell Physiology, The Jikei University School of Medicine
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Akins Robert
Tissue Engineering and Regenerative Medicine Laboratory, Nemours Biomedical Research, Alfred I. duPont Hospital for Children
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