Effect of Transforming Growth Factor Beta-1 on the Intracellular Calcium in Cardiac Fibroblasts.
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概要
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We attempted to determine the effects of transforming growth factor beta-1 on intracellular Ca2+ concentration changes in the presence of isoproterenol in cardiac fibroblasts.Transforming growth factor beta-1 inhibited the increase of intracellular Ca2+ concentration in the presence of isoproterenol in fibroblasts. It also inhibited the production of cyclic-AMP in fibroblasts in the presence of isoproterenol. Islet-activating protein did not block these reactions of transforming growth factor beta-1. Forskolin did not affect the intracellular calcium concentration change resulting from treatment with transforming growth factor beta-1. Binding of [3H]CGP-12177 was decreased to 47% of control preincubated for 24 hours with transforming growth factor beta-1 in fibroblasts. Scatchard plots suggested a decrease in beta-adrenergic receptor number without specific change in receptor affinity.These results suggested that transforming growth factor beta-1 modulates the signal transduction through beta-adrenergic receptor and intracellular Ca2+ concentration by regulating the number of receptors in fibroblasts.
- International Heart Journal刊行会の論文
著者
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Iizuka Kenji
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Kitabatake Akira
Department Of Cardicvascular Medicine Hokkaidou University
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Kawaguchi Hideaki
Department Of Cardiovascular Medicine Hokkaido University
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Murakami Takeshi
Department Of Accelerator And Medical Physics National Institute Of Radiological Sciences
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Kitabatake Akira
Department of Cardiovascular Medicine, Hokkaido University School of Medicine
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