Edematous Arterial Reaction by Adrenaline and Cholesterol and Its Prevention by MAO Inhibitor Observed by Electron Microscopic Technique
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概要
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In 134 rabbits specimens of the aorta were sampled in situ at several time-intervals after the one-shot treatment of animals with several doses of adrenaline, of noradrenaline, of cholesterol or of soybean oil and were observed under the light and electron microscope comparing with the specimens of untreated animals or of animals treated by physiological saline.Small doses of adrenaline (0.1 and 1.0μg. per Kg. i.v.) or cholesterol (1.0 and 3.0Gm. per Kg. p.o.) induced an edematous reaction of the aortic wall, while large doses of adrenaline (10.0 and 100.0μg per Kg. i.v.), noradrenaline (0.1, 1.0, 10.0, and 100.0μg per Kg. i.v.) and soybean oil (5Gm. per Kg. p.o.) did not. The edematous reaction consisted of an enlargement of amorphous extracellular spaces in the subendothelial and medial layers accompanied by a fractionation of elastic fibres along their collagen filaments and a dissociation of collagen fibrils. A sticking of platelets and leucoytes as well as of flake and strand-like substances to the endothelial surface was often encountered.In the case of adrenaline the edematous changes started 5 minutes after the challenge, increased for 30 to 60 minutes and recovered within 2 hours. In the case of cholesterol they started 30 minutes after the challenge, became marked at 1 to 2 hours and disappeared 4 to 6 hours thereafter. The reaction seemed to start from the outer portion of the media and to progress into the inner portion of the media and into the sub-endothelial layer. The recovery took place first in the outer portion of the media, and it was delayed in the inner portion of the medial and subendothelial layer. There was no evidence indicating the increased uptake of plasma) fluid directly from the vessel lumen.The edematous changes produced by adrenaline as well as by cholesterol were minimal or absent in animals pretreated with 5mg. per Kg. of nialamide.
- International Heart Journal刊行会の論文
著者
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SHIMAMOTO T.
Department of Clinical Physiology and Medicine, Tokyo Medical and Dental University
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SHIMAMOTO Takio
Department of Clinical Physiology and Medicine, Tokyo Medical and Dental University, School of Medicine
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SUNAGA Toshiaki
Department of Clinical Physiology and Medicine, Tokyo Medical and Dental University, School of Medicine
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