Histopathological Investigation of Various Organs in Myocardial Ischemic Rats (MIR)
スポンサーリンク
概要
- 論文の詳細を見る
MIR, the first available experimental models, are prone to develop ischemic heart disease spontaneously, and they can be regarded as an animal model for scattered-type of myocardial infarction. In this study, histo-pathological examination of MIR which were fed normal diet and died naturally, revealed systemic vascular changes including coronary arteries frequently asso-ciated with thrombosis. These histological findings were also noted in some cases of SHRSP from which MIR was derived, but vascural obstructive changes in general appeared to be dominant in MIR, in which some additional factors related to thrombosis were supposed to be involved. Moreover, alterations in coronary arteries were more marked in MIR than in SHRSP which died mainly from stroke without severe myocardial lesions. Therefore, it can be concluded that MIR is a useful animal model for studying mechanisms and prevention of coronary heart diseases.
- International Heart Journal刊行会の論文
著者
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Yamori Yukio
Dept. Of Pathology Kyoto Univ. School Of Med.
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Kihara Masahiro
Dept. of Pathol., Shimane Med. Univ.
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Mano Masayuki
Dept. of Pathology, Shimane Med. Univ.
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Nara Yasuo
Dept. of Pathology, Shimane Medical University
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Horie Ryoichi
Dept. of Pathology, Shimane Medical University
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Tsubouchi Toshinori
Dept. of Pathology, Shimane Med. Univ.
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Horie Ryoichi
Dept. of Pathology, and Neurosurgery, Shimane Medical Univ.
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Kihara Masahiro
Dept. of Pathology, Shimane Med. Univ.
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