Reduction of Experimentally Produced Acute Myocardial Infarction Size by a New Synthetic Inhibitor, NCO-700, Against Calcium-Activated Neutral Protease
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概要
- 論文の詳細を見る
Calcium-activated neutral protease (CANP) might be involved in the irreversible degradation of myocardial proteins in the ischemic region, leading to the loss of contractility. The new compound, NCO-700, and its analogues were synthetized against CANP. Among these analogues, NCO-700 was the most potent to reduce the size of acute myocardial infarction, which was produced by coronary artery ligation in rabbits, in vivo, although it showed less powerful action to inhibit CANP activity in vitro. The new reagent, NCO-700 might be promising to reduce acute myocardial infarction size and beneficial for the clinical studies, because it had no action to reduce cardiac muscle contractility, compared with beta antagonist or calcium-channel blockades.
- International Heart Journal刊行会の論文
著者
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Toyo-oka Teruhiko
Department Of Cardiology Jichi Medical School
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MASAKI Tomoh
Tokyo Metropolitan Institute of Medical Sciences
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KAMISHIRO Toshiro
Tokyo Metropolitan Institute of Medical Sciences, Research Institute
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MASAKI Mitsuo
Nippon Chemiphar Co
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MASAKI Tomoh
Tokyo Metropolitan Institute of Medical Sciences, Research Institute
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