Cardiomyopathy in Myotonic Dystrophy : A Light and Electron Microscopic Study of the Myocardium

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概要

• 論文の詳細を見る

• A case of 31-year-old woman with myotonic dystrophy who developed only slight cardiac symptoms has been reported. Light and electron microscopic study was performed on myocardium obtained with endomyocardial biopsy.Light microscopy revealed a considerable degree of fatty infiltration in the myocardium, slight interstitial fibrosis and degenerated myocardial cells. On electron microscopy, marked mitochondriosis and a small number of vacuoles consisting of single limiting membrane and indefinite content low in electron density were observed. Peculiar intranuclear structure and myofibrils showing partial over-contraction and indistinct Z band were also present, and these findings were discussed comparing with the previous reports.Endomyocardial biopsy seemed to be very useful to detect the myocardial changes even in the early stage of this disease, and the electron microscopic examination of the myocardium may provide the finding which is pathognomonic for the development of the cardiomyopathy in myotonic dystrophy.

• International Heart Journal刊行会の論文

著者

• Tanaka Nobuyuki

  Kagoshima University Hospital Kirishima Branch

• Tanaka Nobuyuki

  First Department of Internal Medicine, Osaka City University Medical School

• TANAKA HIROMITSU

  First Department of Medicine, Kagoshima University School of Medicine

• Kanehisa Takuya

  First Department of Internal Medicine

• TAKEDA Motohiko

  First Department of Internal Medicine, Faculty of Medicine, Kagoshima University

• NIIMURA Tatsuru

  First Department of Internal Medicine, Faculty of Medicine, Kagoshima University

• TERASHI Shin-ichi

  First Department of Pathology, Faculty of Medicine, Kagoshima University

• Tanaka Nobuyuki

  Dept. Of Intern. Med. Kagoshima Univ. School Of Med.

• Tanaka Hiromitsu

  First Department Of Internal Medicine Faculty Of Medicine Kagoshima University

• TANAKA Nobuyuki

  First Department of Internal Medicine, Faculty of Medicine, Kagoshima University

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