Age-Related Differences in Tolerance to Digoxin : Lower Digoxin Concentration in Myocardial Microsornal Fraction in Infant Rats
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the mechanism responsible for age-related differences in tolerance to digitalis, we studied the potassium contents of serum and myocardium and the digoxin concentrations of serum, myocardium, and myocardial microsomal fraction in infant and adult rats. While serum potassium concentration was the same in both infant and adult rats, the potassium content of myocardium found in the infant rats was significantly higher than that in the adult ones. Digoxin concentration of serum in infant rats was lower than that in the adult ones after a bolus injection of the same dose of digoxin per kilogram of body weight was given. Digoxin concentration of microsomal fraction, obtained 1 hour after the administration of 0.2mg/Kg of digoxin in infant rats, was lower than that obtained 1 hour after the administration of 0.1mg/Kg of digoxin in adult ones even though the digoxin concentrations of serum and myocardium in infant rats were significantly higher than those obtained in adult ones. Thus, less sensitivity to digitalis found in infant rats may be attributable to the higher potassium content of myocardium and the lower digoxin concentration of microsomal fraction.
- International Heart Journal刊行会の論文
著者
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SAITO Kazuto
Health Service Center of National Institute of Fitness and sports in Kanoya
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Tanaka Nobuyuki
First Department of Internal Medicine, Osaka City University Medical School
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TANAKA HIROMITSU
First Department of Medicine, Kagoshima University School of Medicine
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Saito Kazuto
The Health Service Center National Institute Of Fitness And Sports
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SAITO Kazuto
First Department of Internal Medicine, School of Medicine, Kagoshima University
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KASHIMA Tomoyoshi
First Department of Internal Medicine, School of Medicine, Kagoshima University
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Saitou Kazuto
The First Department Of Internal Medicine Faculty Of Medicine Kagoshima University
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Tanaka Hiromitsu
First Department Of Internal Medicine Faculty Of Medicine Kagoshima University
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KASHIMA Tomoyoshi
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University
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TANAKA Nobuyuki
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University
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TANAKA Nobuyuki
First Department of Internal Medicine, School of Medicine, Kagoshima University
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TANAKA Hiromitsu
First Department of Internal Medicine, School of Medicine, Kagoshima University
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SAITO Kazuto
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University
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