Effect of Cesium on the Properties of Cardiac Muscle

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概要

• 論文の詳細を見る

• The effects of cesium, potassium and propranolol on the automaticity of spontaneously beating right atria; the excitability and contractility of left atria and papillary muscles; and the A-V conduction of the guineapig heart were investigated. Cesium like potassium and propranolol produced a negative chronotropic effect and a decrease in the A-V conduction. Cesium increased the excitability and contractility. Both potassium and propranolol decreased the contractility. While potassium (4mM) increased the excitability, propranolol (2μg/ml) decreased it. Cesium always produced an increase in the excitability in the left atria but in lower concentration (2mM) it produced a decrease in the excitability in papillary muscles. Although propranolol decreased the excitability more in the papillary muscles than in the left atria, it produced almost an equal depression of contractility in the left atria and papillary muscles. Cesium might be a better antiarrhythmic agent than propranolol and potassium because its antiarrhythmic activity is not associated with cardiac depression.

• International Heart Journal刊行会の論文

著者

• Prasad K.

  Department Of Biology And Program In Molecular Plant Biology Colorado State University

• MIDHA K.

  Department of Physiology, Faculty of Medicine, University of Saskatchewan

• PRASAD K.

  Department of Physiology, Faculty of Medicine, University of Saskatchewan

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