Hemodynamics of Hyperthyroidism : The Effects of Autonomic Nervous Blocking and Anti-Thyroid Drug Treatment

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This work was intended to analyze the sympathetic and parasympathetic factors affecting the hemodynamics of hyperthyroidism. Seven patients with hyperthyroidism, diagnosed based on the determinations of BMR, 131I-uptake, T3-resin sponge uptake (T3-RSU), and serum level of thyroxine (T4) were subjected to the study. The hemodynamic estimation was done (1) at rest, (2) after vagus blocking by the injection of 0.04mg/Kg b.wt. atropine and 0.2mg/Kg b.wt. propranolol before (hyperthyroid state=H) and after (euthyroid state=E) antithyroid drug therapy. Cardiac output was measured by the dye-dilution method, and the value was calculated according to the standard Hamilton formula. The following results were obtained. (1) The vagal tone is lower in H than in E, on the other hand, sympathetic β-receptor tone is higher in H than in E. (2) The sympathetic α-receptor tone in H may be equivalent to that in E. (3) There might exist inotropic factors which affect the hemodynamics, other than autonomic nervous system in H.
International Heart Journal刊行会の論文