Three Cases of Sinoatrial Block Induced by Anticonvulsants
スポンサーリンク
概要
- 論文の詳細を見る
Diphenylhydantoin (DPH) and Carbamazepine have been widely used as anticonvulsants and known to have antiarrhythmic properties. Previous reports have shown that arrhythmias such as sinus bradycardia and atrioventricular block can be induced by these agents. In this paper, sinoatrial block (SA block) induced by these agents which were used as anticonvulsants in 3 aged patients is reported.Three patients, 2 women and 1 man, were over 60 years old. In 2 cases, administration of DPH for recurrent epileptic seizures was followed by SA block. After withdrawal of DPH, SA block disappeared, but resumption of DPH resulted in SA block again. In 1 of these 2 patients, overdrive suppression test revealed normal sinus node recovery time. In the third patient, in addition to DPH which was administered for epileptic seizures, Carbamazepine was given for shoulder pain, then SA block occurred. Withdrawal of these agents restored normal sinus rhythm and combined administration of these 2 agents again induced SA block. Autopsy revealed decreased conduction cells in the sinus node.
- International Heart Journal刊行会の論文
著者
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Ide Hiroshi
Division Of Cardiology Tokyo Metropolitan Geriatric Hospital
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Takayanagi Kan
Division of Cardiology,Tokyo Metropolitan Geriatric Hospital,the Second Dept.Med. , and tlle Dept.of
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Ueda Keiji
Division of Cardiology,Tokyo Metropolitan Geriatric Hospital,the Second Dept.Med. , and tlle Dept.of
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Ohkawa Shinichiro
Division of Cardiology,Tokyo Metropolitan Geriatric Hospital,the Second Dept.Med. , and tlle Dept.of
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Mifune Junichiro
Division of Cardiology,Tokyo Metropolitan Geriatric Hospital,the Second Dept.Med. , and tlle Dept.of
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Sugiura Masaya
Division of Cardiology,Tokyo Metropolitan Geriatric Hospital,the Second Dept.Med. , and tlle Dept.of
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INOUE Hiroshi
Division of Genetic Information, Institute for Genome Research, The University of Tokushima
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Ueda Keiji
Division Of Cardiology Tokyo Metropolitan Geriatric Hospital
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Inoue Hiroshi
Division Of Genetic Information Institute For Genome Research The University Of Tokushima
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Sugiura Masaya
Division Of Cardiology Tokyo Metoropolitan Hiroo General Hospital
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OHKAWA Shinichiro
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital
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MIFUNE Junichiro
Division of Cardiology, Department of Medicine, Tokyo Metropolitan Geriatric Hospital
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MIFUNE Junichiro
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital
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TAKAYANAGI Kan
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital
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INOUE Hiroshi
Division of Cardiology, Department of Medicine, Tokyo Metropolitan Geriatric Hospital
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INOUE Hiroshi
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital
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