Evidence of Hypovitaminosis D in Patients with Mitral Ring Calcification

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In order to evaluate the role of calcium regulating hormones in the pathogenesis of mitral ring calcification, we have studied the serum levels of PTH and vitamin D metabolites in aged females both with and without mitral ring calcification (MRC).In the patients with MRC (n=17), significantly lower levels of serum total protein (6.6±0.2 in the MRC group vs 7.1±0.1g/dl in the control group, mean±SEM), BUN (15.7±0.9 vs 18.3±0.9mg/dl), creatinine (0.7±0.02 vs 0.9±0.02mg/dl) and calcium (8.4±0.1 vs 9.2±0.1mg/ml) were observed as compared with those in the controls (n=32). Significantly higher PTH levels (0.57±0.07 vs 0.38±0.04ng/ml) were found in the MRC group. Levels of all three vitamin D metabolites in the MRC group were significantly lower than those in the control group (25-OHD; 11.2±1.4 vs 19.6±1.2ng/mMl, 24, 25 (OH)2D; 0.7±0.1 vs 1.3±0.1ng/ml and 1, 25 (OH)2D; 12.5±2.4 vs 43.0±3.5pg/ml). The correlation coefficient between PTH and 1, 25 (OH)2D was -0.382 (n=49, p<0.01). Thus, the significantly higher PTH levels in the MRC group might result in hypovitaminosis D.In conclusion, evidence of hypovitaminosis D in the patients with mitral ring calcification was demonstrated.