The Effect of Alcohol on Active and Passive Stiffness, and on Isometric Contractions of Glycerinated Heart Muscle in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The response of the contractile and the series elastic elements to ethanol was studied isometric contraction and quick release methods after measuring the passive length-tension relationship in glycerinated heart muscle fibers of rats at resting state. In rats consuming 30% ethanol for an average of 5 weeks, maximal developed tension (P0), the maximal rate of tension development (dp/dtmax) and Vmax were significantly depressed, the time to peak tension (t0) was not changed. As in fresh papillary muscle the modulus of elasticity of active glycerinated muscle increased in proportion to load. The stiffness of the series elastic element showed significant elevation in rats receiving ethanol. The passive stiffness in resting state revealed no significant difference between control and alcohol exposed rats. Therefore, increased stiffness of the series elastic element and diminished contractility are present following chronic alcohol consumption.
- International Heart Journal刊行会の論文
著者
-
Bing Richard
Huntington Medical Research Institutes
-
MARUYAMA Yukio
Huntington Institute of Applied Medical Research and the Huntington Memorial Hospital the University
-
SARMA J.S.M.
Huntington Institute of Applied Medical Research and the Huntington Memorial Hospital the University
-
WEISHAAR Ronald
Huntington Institute of Applied Medical Research and the Huntington Memorial Hospital the University
-
SARMA J.S.M.
Huntington Institute of Applied Medical Research and the Huntington Memorial Hospital the University of Southern California, and the California Institute of Technology
-
WEISHAAR Ronald
Huntington Institute of Applied Medical Research and the Huntington Memorial Hospital the University of Southern California, and the California Institute of Technology
関連論文
- 0716 急性心筋梗塞におけるiNOSの選択的阻害による心機能の改善効果
- 0716 IMPROVEMENT OF CARDIAC FUNCTION BY iNOS SELECTIVE INHIBITION IN EXPERIMENTAL MYOCARDIAL INFARCTION
- Blood Flow Velocity in the Carotid Artery as a Measure of Myocardial Contractility
- THE EFFECT OF EXPERIMENTAL ATHEROSCLEROSIS ON LYSOLECITHIN-INDUCED VASORELAXATION : Pathophysiology : 53 Annual Scientific Meeting, Japanese Circulation Society
- The Effect of Alcohol on Active and Passive Stiffness, and on Isometric Contractions of Glycerinated Heart Muscle in Rats