Dale′s principleについて--いわゆる1ニュ-ロン1伝達物質説をめぐって

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概要

• 論文の詳細を見る

• Dale's principle was first proposed by Eccles in 1954 based on 3 lectures given by Dale in 1934 and 1952. Many authors in the literature define Dale's principle as the "one neuron-one transmitter concept". The origin of such an idea, however, is rather vague. Neither Dale nor Eccles stated literally the one neuron-one transmitter concept. It seems now appropriate to define Dale's principle according to Eccles (1976) as follows: "at all the axonal branches of a neuron there is liberation of the same transmitter substance or substances". Recent studies showed examples that are not in accord with the "one neuron-one transmitter concept". Many cases were shown in which a neuron contains more than one transmitter. Whether this is a common rule or exceptional remains to be clarified by future studies.

• 社団法人 日本薬理学会の論文

著者

• 大塚 正徳

  東京医科歯科大学医学部薬理学教室

• 大塚 正徳

  東京医科歯科大学

関連論文

• 2. 神経伝達物質
• Dale′s principleについて--いわゆる1ニュ-ロン1伝達物質説をめぐって
• アミノ酸と化学伝達物質(脳と神経の研究V)

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