実験的糖尿病ラットの組織内Norepinephrine,血漿NEFA,Glucoseおよび結腸温に対する寒冷刺激の影響について
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Correlation between urinary catecholamine (CA) and various endocrine diseases has been reported by many authors. The effect of cold stress on the sympathetic nervous system (particularly tissue CA levels) under patho-physiological stage, however, is not well known. This experiment dealt with the effect of cold stress on tissue norepinephrine (NE), plasma NEFA, glucose and colonic temp. in alloxan diabetic rats in order to investigate the role of the sympathetic nervous system in diabetes mellitus. Cardiac NE of diabetic rats was decreased to about one half that of control, however, brain NE was not statistically altered. When diabetic rats were exposed to cold for several hr, cardiac NE was even more decreased. On the contrary, brain NE was increased significantly all the periods. Plasma NEFA and glucose of diabetic rats were significantly increased compared to control values. When these animals were exposed to cold, both were increased markedly for the first 30min, but thereafter showed a tendency of decrease and in particular plasma glucose showed a lower value than diabetic control value after 6hr. Absolute values of both substrates, however, were still higher than control values after 6hr periods. Colonic temp. fell markedly, but showed a tendency to recover within 3 to 6hr. These results indicate that the sympathetic nervous system in alloxan diabetes is stimulated and the decreased cardiac NE may reveal an attempt to remedy the low intracellular glucose level. More marked changes were observed in diabetic rats exposed to cold.
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