特異的および非特異的刺激物質に対するモルモット摘出胆のう収縮反応に及ぼすButoxybenzyl hyoscyamine bromideの影響
スポンサーリンク
概要
- 論文の詳細を見る
Effects of butoxybenzyl hyoscyamine bromide (BBHB) on contractile response of isolated guinea-pig gallbladder to specific and non-specific stimulants were examined. Results are as follows: 1) BBHB, in low concentrations (10-9_??_10-6M), exerted an atropine-like competitive blocking action against the acetylcholine (ACh)-induced contraction. The affinity to muscarinic receptor of BBHB (pA2=8.79±0.08, molar unit) was greater than that of atropine (pA2=7.64±0.12, molar unit). 2) BBHB, in high concentrations (5×10-6_??_4×10-4M), showed non-competivity blocking action against the KCl-induced contraction (pD2=3.30±0.06) and the BaCl2-induced contraction (pD2=3.12±0.15). The affinity of BBHB was somewhat less than that of papaverine (pD2=4.80±0.11 to BaCl2 and 4.81±0.05 to KCl). 3) In the Ca++-free medium, high concentrations of BBHB inhibited noncompetitively the BaCl2-induced contraction, the pD2 value being 3.05±0.12, however BBHB, even in a high concentration, did not affect the Ca++-induced contraction of K+-depolarized preparation in Ca++-free medium. On the other hand, papaverine antagonized noncompetitively the Ba++-induced contraction (pD2=4.56±0.21) and the Ca++-induced contraction (pD2 =4.75 ±0.03). These results suggest that BBHB, in low concentrations, antagonizes competitively the ACh-induced contraction at muscarinic receptors, whereas in gigh concentrations reduced K+-induced and Ba++-induced contractions, presumably by interfering with the K+- and Ba++-induced inward release of membrane-bound calcium, by decreasing the Ba++-influx and/or by preventing the barium ion from being utilized by the contractile proteins.
- 社団法人 日本薬理学会の論文
著者
関連論文
- B17 生長抑制物貭の作用機構 : 酵素組織化学的研究
- 135 犬および人における門脈平滑筋の部位差(第27回日本消化器外科学会総会)
- Nicorandilの血管弛緩作用 ―Nitroglycerin，Caアンタゴニストとの比較―
- 摘出静脈条片におよぼすGlucofuranosideの影響
- Tofisopamの胃機能に及ぼす影響
- 50. 胃 enterochrome 親様細胞に関する螢光組織化学的研究
- Reserpineならびに誘導体の血圧およびAmine量に対する影響
- ミカン科キハダ含有第四級Ammonium塩基Phellodendrineの一般薬理作用に就て
- 経壁刺激および化学刺激に対する摘出モルモット胆のうの収縮反応に及ぼす低温保存の影響
- 特異的および非特異的刺激物質に対するモルモット摘出胆のう収縮反応に及ぼすButoxybenzyl hyoscyamine bromideの影響
- 4-Methylumbelliferoneの鎮痙作用機序
- オクテット
- Guaiacol glycerol ether mononicatinateの循環作用-1-
- Endothelial cell-dependent reactions of the cerebral and coronary arteries. Relationship of receptor-agonistic Ca2+ channel.