一般薬理作用 (新Minor tranquilizer,dipotassium chlorazepate(7-chloro-1,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzo diazepine 3-carboxylic acid monopotassium salt monopotassium hydroxide)に関する薬理学的研究-1,2-)

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Pharmacological properties of a new minor tranquilizer, dipotassium chlorazepate (CAP) were examined. The results obtained were as follows: (1) CAP in lower doses had no significant effects on cardiovascular or respiratory system. Cardiovascular changes induced by acetylcholine or nicotine, except epinephrine were not affected by CAP. Cardiovascular change induced by epinephrine was potentiated by the preadministration of CAP. (2) CAP had no ganglion blocking action. (3) CAP did not affect on monosynaptic reflex, but it had inhibitory effect on polysynaptic reflex. (4) CAP had no effect on neuromuscular junction. (5) CAP at lower doses had almost no effect on isolated atria, intestine and uterus, and at higher doses it had no antihistaminic action. (6) CAP had almost no effect on carrageenin induced edema and pigment transduction. (7) CAP had no significant effects on urinary volume and urinary electrolyte excretion. (8) CAP had no effect on the size of pupil. (9) CAP decreased both normal body temperature and pyrogene induced hyperthermia.
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