炎症初期における一,二の抗炎症剤の薬理作用に関する研究

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概要

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• This study was undertaken to ascertain the difference between serratiopeptidase, a new anti-inflammatory-enzymatic drug, and aminopyrine, a time-honoured anti-inflammatory drug, in the mechanism of changes of the vascular permiability and the cellular infiltration that is a factor of inflammation in early stage.Results: 1. A macroscopic swelling induced by the dextran injection in the hind paws of rat was apparently inhibited due to the oral administration of serratiopeptidase (500mg/kg) or aminopyrine (100mg/kg); those were administrated 3 hours before the dextran injection or at the same time of this injection. And this swelling was slightly inhibited due to aminopyrine that was injected 3 hours after the dextran injection, too. 2. As for the influences on changes of vascular permiability induced by evans blue in the abdominal skin of rat, both serratiopeptidase and aminopyrine administrtaed orally 3 hours before the concentration of pigmentation by evans blue. When both drugs were adminstrated at the same time or 3 hours after the dextran injection, they could not inhibit the enlargement of the area of pigmentation, but as for the concentration serratiopeptidase inhibited it apparently and aminopyrine did it slightly. 3. In any time of the administration of the drugs, serratiopeptidase apparently inhibited the histo-pathological edema, but weakly the cellulal infiltration. On the contrary, aminopyrine apparently inhibited the cellular infiltration, but weakly the histopathological edema. From the above results, the difference of the inhibitory effects on the inflammation in early stage was ascertained clearly between serratiopeptidase and aminopyrine.

• 社団法人 日本薬理学会の論文

著者

• 薄井 康弘

  東京歯科大学薬理学教室

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• 炎症初期における一,二の抗炎症剤の薬理作用に関する研究

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