膜標本の(Na++K+)-activated ATPase活性に対するOuabain抑制の種属差

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In order to know the reason for the species difference in the in vivo sensitivity to ouabain, the (Na+-K+)-activated adenosine triphosphatase (ATPase) activity of prepared cell membrane from heart and skeletal muscles was observed in several animals. The ratio of ouabain concentration which caused 50 % inhibition of activity of the enzyme from hearts of cat, guinea pig, rat and bufo was obtained in 1: 4: 80: 660, which was approximately the same as the ratio of lethal dose in these animals (1 : 3 : 150: 1000). In the course of this study, a stage was found that (Na+-K+)-activated ATPase activity was not inhibited in presence of manifest positive inotropic effect of ouabain, using ouabain-infused cat heart.
社団法人日本薬理学会の論文