各種動物に対する強心配糖体の毒性と心筋内濃度との関係
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概要
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Comparative studies on lethal dose of digitoxin and <I>post-mortem</I> concentration of the drug in heart muscle were made in cat, guinea pig and rat. It was found that relative ratios of lethal dose for these animals were 1: 2.5: 60 and that relative concentration ratios of digitoxin were 1: 9: 70.<BR> When atria was prepared for recording twitch tension, digitoxin (2.2 × 10<SUP>-7</SUP> g/ml) initially increased and then reduced the tension. In the rat, the time for 50 % decline in peak tension was four times longer than that in the guinea pig, whereas uptake of <SUP>3</SUP>H-digitoxin by atria was almost the same in both animals. From the results obtained, it could be concluded that the in vivo sensitivity to digitoxin might be in parallel with sensitivity of heart muscle to the drug.
- 社団法人 日本薬理学会の論文