AdrenalineによるThiopental麻酔の強化
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概要
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Animals receiving catecholamines on awakening from barbiturates anesthesia returned to sleep. Furthermore, animals pretreated with adrenaline showed a significant prolongation of thiopental sleeping time. The analytical data demonstrated that this potentiating effect of catecholamines which was blocked by the adrenolytic agents was attributed to an increased penetration of thiopental into the brain. On the basis of <I>in vitro</I> experiment, the possibility that adrenaline might exert the potentiating effect on the thiopental anesthesia through its lipolytic action was suggested.
- 社団法人 日本薬理学会の論文