脂肪酸によるThiopental麻酔の強化

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概要

• 論文の詳細を見る

• The potentiating effect of oleate on the thiopental anesthesia was confirmed by the following: 1) prolongation of sleeping time, 2) return to sleep on recovery and 3) reduction of anesthetic doses. An intravenous administration of oleate to animals under thiopental anesthesia was found to increase the brain thiopental levels. From the results of <I>in vitro</I> thiopental penetration experiment, it was found that oleate increased unbound, freely diffusible thiopental. This increase was probably due to the capacity of the fatty acid to usurp albumin binding sites of thiopental. The inhibitory effect of various fatty acids on thiopental binding to albumin was studied by the technique of ultrafiltration.

• 社団法人 日本薬理学会の論文

著者

• 大宮 彬男

  北海道上川保健所

• 大宮 彬男

  札幌医科大学薬理学教室

関連論文

• 追悼
• 脂肪酸によるThiopental麻酔の強化
• AdrenalineによるThiopental麻酔の強化

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