Sulfonamide諸誘導体の薬理学的研究-2-

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With the first sample of promin prepared in this country, examinations were carried out by the author during the war-time. Toxic symptoms observed in mice and rats were indicative of a close resemblance of the compound in its toxicity to the mother compound, 4 : 4'-diaminodiphenylsulfone. LD<SUB>50</SUB> for mice were 3.93 g. per kg of body-weight by mouth, 6.5 g subcutaneously and 45.25 g. intravenously, and for rats almost the same readings in the respective potencies were obtained. It was revealed that the oral toxicity of promin exceeded the parenteral one, not only in a single dose but also when given repeatedly for a certain period. Kymographic examinations for respiratory and cardiovascular responses were conducted in rabbits and frogs. The fall in blood-pressure in rabbits, the presence of temporary cyanosis and the local irritation or edematous swelling of skin in rats were the noticeable findings observed by the author. Examinations on the bronchial instillation were given to rule out some possible but untoward reactions of the drug ingested through the tracheal puncture.
社団法人日本薬理学会の論文