Sulfonamide諸誘導体の薬理学的研究-1-
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概要
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Toxic symptoms of several preparations were fully observed and their lethal doses were determined. LD50 of sulfamin (J.P.) for mice was 3.0g/ kg by mouth and was less than two thirds of it when used subcutaneously, and that of pyridinine was 2.1g/kg by mouth. Disulfamin and sulfathia ole were both too weak to obtain LD50 orally. 4 : 4'-Dinitrodiphenylsulfoxide and sulfone were both about one half toxic as compared with sulfamin. With 4:4'-diaminodiphenylsulfone an ataxic symptom was unfailingly manifest and hence the 50 per cent ataxic dose proved available for judging its toxicity along with the lethal dose; LD50 per kg for mice were 375 mg by mouth, 329 mg subcutaneously, and 313 mg intraperitoneally, and its 50 per cent ataxic dose 228 mg, 221 mg and 110 mg respectively and the repeated administrations with various intervals revealed that there was a close and simple relation between the toxic effects and the actual doses, as indicating a high rate of its absorption and excretion.
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